New antibacterial substance class against MRSA – suitable for the treatment of medically relevant surfaces
A new structural class with antibiotic activity was developed from the privileged structure of bacterial signal molecules. The compounds are characterized by a high level of activity and selectivity against pathogenic bacteria with a low toxicity against human cells. There is thus the possibility of licensing a new antibiotic class that inhibits both methicillin-resistant staphylococcus aureus (MRSA) and gram-negative human pathogens such as Moraxella and Neisseria species. Moreover, it can be used for the impregnation of materials and surfaces.
According to the Federal Ministry of Health 400,000 to 600,000 patients contract a hospital-acquired, or nosocomial, infection, each year. 10,000 to 15,000 of them die as a result (as of 5 April 2017). Surfaces like those of urinary catheters rank among the greatest sources of infections. There is a continuous evolution of the germs themselves and therefore also of new resistances.
Despite the ever-growing number of new resistant germs, it seems as if today the economic incentive for developing new active substance classes is decreasing. The number of new classes of antibiotics worldwide has been declining for years now. Their development is a tedious and expensive process; new drugs can only have a trustworthy effect for a short period of time before new resistances arise. This trend is dangerous for all of us, because MRSA is propagating, especially where we are most vulnerable – in hospitals worldwide. On top of this it is getting more and more difficult to identify new substance classes – the range seems to be increasingly exhausted.
As part of a research project at the University of Konstanz funded by the DFG (German Research Foundation), the Marie-Curie ZIF Zukunftskolleg scholarship and by FCI (Fonds der Chemischen Industrie), the scientists succeeded in developing a completely new class of antibiotics, which is also highly effective against multi-resistant pathogens such as S. aureus. This could be demonstrated in vitro in cells of several pathogenic and non-pathogenic bacteria. The active substances according to the invention have a new chemical structure that derives from the molecular signals PQS and HHQ, two important factors in microbial communication. These “quorum-sensing” signals usually coordinate the virulence of pathogenic bacteria. For those new structures that are now used against them, there are obviously no mechanisms of resistance yet. Due to the fact that the active substance can also be used for the embedding into different materials, future infections caused by medical surfaces as those of urinary catheters could thus be prevented as well
- A new type of highly effective class of antibiotics
- Bypassing of existing resistances
- Effective against pathogenic MRSA strains
- Effective against gram-positive pathogens
- Effective against gram-negative pathogens
- Low toxicity against human cells
- Laboratory-confirmed efficacy
- Active substances suitable for the treatment and disinfection of material surfaces (medical instruments, etc.)
Antibiotics are one of the greatest medical achievements; only a few decades ago bacterial infections like pneumonia, scarlet fever or syphilis caused a lot of victims. Today, these diseases can be treated successfully. However, multi-resistant germs are becoming a growing threat. This is due to the fact that they are already resistant to most of the classes of antibiotics currently available.
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Michaela Prothiwa, David Szamosvari, Thomas Böttcher,
"Wie Bakterien uns mit Naturstoffen krank machen."