Technology Offers Medical Technology



Fully automated relocalization of areas of interest on any automated light microscopy system

This technique offers for the first time the possibility of reliable correlative microscopy by means of a cost-effective extension of existing systems. - Identify objects and view them in different systems without any offset!
This platform-independent method opens up a new dimension in automated microscopy and optimizes analyses in all areas of multi-scale imaging.

 

 

Adaptive mini-lenses for high-resolution magnetic resonance imaging using integrated light microscopy

Thanks to a newly developed adaptive and interference-insensitive mini-optic, high-resolution magnetic resonance imaging can now be performed with integrated light microscopy. The combination also paves new ways for medical diagnostics.

 

 

Esophagus electrode probe and method for cardiological treatment and diagnosis

This innovative esophageal catheter has advanced sensors and electrodes that enable comprehensive tissue parameters to be recorded during catheter ablation. Additional sensor technology on the remote side of the heart not only enables reference measurements that allow comprehensive monitoring and thus increase patient safety; hemodynamic monitoring and pain reduction in transesophageal electrostimulation are also possible.

 

 

Marker-free, high-content screening for digital pathology

Researchers at Reutlingen University have succeeded in developing a marker-free method that allows for the characterization of chromosomes, cells and tissue sections in terms of their chemical properties (absorbance) and their morphological properties (scattered light). Measurements were carried out in ultraviolet and visible light, with a compact spectrometer module that can easily and inexpensively be built into a standard microscope or an automated screening tool.
By implementing an additional function into high-content screening systems it is now possible to make a demarcation between the tumor and the physiological tissue.

 

 

New possibilities for surgical treatment of glioblastomas

Researchers at Reutlingen University have succeeded in developing a marker-free method that allows for the characterization of chromosomes, cells and tissue sections in terms of their chemical properties (absorbance) and their morphological properties (scattered light). Measurements were carried out in ultraviolet and visible light, with a compact spectrometer module that can easily and inexpensively be built into a standard microscope or an automated screening tool.
By implementing an additional function into high-content screening systems it is now possible to make a demarcation between the tumor and the physiological tissue.The spectroscopic measuring unit can be easily fixed to a surgical microscope or endoscope. The resulting image or image section is immediately qualified and used by the surgeon for decision-making.

 

 

Innovative coating for implants for improved ingrowth into the bone

Scientists at the Universities of Stuttgart and Constance have developed a technology which should significantly improve ingrowth of implants into the surrounding tissue and at the same time ensure long-term stability.
A new type of implant coating created of a non-water-soluble, functionalized extracellular matrix (FECM) is achieved by means of metabolic oligosaccharide engineering. The coating improves the cell-material interaction at the interface between tissue and biomaterials (e. g. titanium). Since the patient's own cells can be used to produce the FECM, no immunogenicity of the implant coating is to be feared.

 

 

Marker-free chromosome screening

Researchers at Reutlingen University have succeeded in developing a label-free method for the characterization of metaphase chromosomes. The method and the corresponding analysis algorithm allow for visualization of both the chemical properties (absorption) and the morphological properties (stray light) of a chromosome. Using this method, the bands and sub-bands can be characterized with high resolution. Thus, no staining is required for unambiguous identification. The technology can be integrated into all imaging methods (e.g.microscopy).

 

 

Device for rotation of 3D samples in microscopy or for CAD-modeling & 3D printing

Scientists at Aalen University have developed a device which allows the rotation of samples. It can be used in conjunction with a range of microscopy methods, including single-plane illumination microscopy (SPIM) and laser scanning microscopy. This enables scientists for the first time to observe 3D samples from all sides using conventional microscopes. Since the sample is kept in a fixed position relative to the microscope, the method opens up new possibilities for the 3D reconstruction of samples, for example in combination with single plane imaging.

 

Rotational views of a copepod

 

 

Novel urocatheter for improved diagnosis of urinary incontinence

Scientist at the University of Stuttgart, Germany, have developed a new microtip measuring catheter that is equipped with a triaxial acceleration sensor and several pressure sensors around its circumference. The novel urodynamic catheter has been specifically developed for the diagnosis of urinary incontinence. Its considerable improvement in diagnosis allows for an optimized treatment of incontinence. A prototype of the catheter is currently subject to animal testing.